Modafinil in obstructive sleep apnea-hypopnea
syndrome: a pilot study in 6 patients
by
Arnulf I, Homeyer P, Garma L, Whitelaw WA, Derenne JP.
Service de Pneumologie et Laboratoire du Sommeil,
Hopital Pitie-Salpetriere,
Paris, France.
Respiration 1997; 64(2):159-61

ABSTRACT

We studied the effects of modafinil, a vigilance-enhancing drug, on excessive daytime sleepiness, memory, night sleep and respiration in 6 patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) using a double-blind random cross-over design with 24-hour polysomnography, verbal memory test and a 5-week sleep-wake diary kept by the patients. There were two 2-week treatment periods in which either modafinil or placebo was used; they were separated by a 1-week wash-out period. Our results show that modafinil reduces daytime sleep duration, lengthens the duration of subjective daytime vigilance and improves long-term memory in patients with OSAHS without modifying night sleep and respiration events.

Sleep apnea
Modafinil: structure
Modafinil and serotonin
Modafinil and the aviator
Modafinil: pharmacokinetics
Modafinil as an antidepressant
Modafinil versus amphetamine
Modafinil versus methylphenidate
Modafinil, amphetamine and sleep
Modafinil for daytime sleepiness in obstructive sleep apnea

Refs
and further reading

HOME
HedWeb
Nootropics
cocaine.wiki
Future Opioids
BLTC Research
MDMA/Ecstasy
Superhapiness?
Utopian Surgery?
The Abolitionist Project
The Hedonistic Imperative
The Reproductive Revolution
Critique of Huxley's Brave New World

The Good Drug Guide
The Responsible Parent's Guide
To Healthy Mood Boosters For All The Family